I do have a Focusrite Scarlett 6i6 (2nd Gen) USB interface, and I would like to know if its possible to use it as an Audio interface, so that I can take advantage of its ability to go for higher sampling rate and bit depth (48khz / 24bit) without sacrificing the ability to use the Editor VST for MIDI Recording.

You can certainly use the Focusrite Scarlett 6i6 2nd Gen as your USB Interface. The MOX6 will simply be an audio source at that point. All audio conversion will be handled by the Focusrite (which is capable of sample rates up to 192kHz). So you are fine there. Check with Focusrite for the recommended Driver. Audio input and output will be handled by the Focusrite.

You will need the Yamaha Steinberg USB Driver for multi-Port MIDI communication between the MOX6 and your computer. This means you’ll need a USB connection between the MOX6 and your computer (strictly for MIDI). The MOX6 Editor will use MIDI Port 1 for music communication (Note-Ons, Controllers, Tempo, etc) and MIDI Port 4 for the Editor’s VSTi communication.

When you launch the Editor inside Cubase, you’ll go to File > Setup > select Port 1 to Port 1, and Port 4 to Port 4
Then under File > VSTi Setup > set the Audio Port to use the Focusrite inputs you have the MOX6 connected to... say the MOX6 is connected to inputs 5 and 6 on the Focusrite, you would select them here. This way the MOX6 VST will return Audio to Cubase properly.

If its possible and someone can help me with the routing steps or procedures,it will be a great help for me to program music for videos.

It is certainly possible. You simply connect the 1/4” analog Outputs of the MOX6 to two instrument inputs on the Focusrite.
Connect the Focusrite to your computer via USB (got Audio). Connect the Focusrite Outputs to your monitor speakers or use a quality pair of headphones.

I recommend you have both... there are times you’ll want to move air molecules with speakers and there will be times you’ll want turn the speakers off and record with a microphone. It is then when headphones are essential.

Computer Spec:
Windows 7 32 bit
Cubase AI5

I'll be soon upgrading to Cubase Artist / Pro 10.5 on Win 10 64 bit.

Good, you’ll find that while the hardware synth (MOX6) ages, it ages better than computers and computer software. Cubase AI5 is now *non-compliant* with much of what today’s computers are doing. Computers and software DAWs have moved to 64-bit operations. *Non-compliant* is computer talk for, its old and while it may still work, nobody’s checking anymore. Translation: Please upgrade.

You don’t buy software as much as you subscribe... if you know what I mean.

You’ll want to download... MOX6/MOX8 Editor Standalone / VST V1.6.8 for Win which is 64-bit capable... and will be able to run in Cubase Artist or Pro 10.5 without issue!

So when you upgrade to Window 10 and a newer version of Cubase it should be smooth sailing for your requirements.
I don’t believe Cubase AI5 is able to do this, (and I cannot test it) but with a newer version of Cubase you’ll be fine.

When you get setup, let us know.

Wow!! Thank you Bad Mister for that timely response. I will try it out..:D

Dear Bad Mister,

Is my Yamaha MOX with V.1.00 is good enough to integrate with cubase 10.5 or is it mandatory to update to OS V.1.20.?

I’m unaware of any firmware update available for the MOX6.

https://usa.yamaha.com/support/updates/52865_en.html

I meant this Bad Mister, V1.02.

Meanwhile, I connected my MOX along with the Focusrite scarlett 6i6 to Cubase 10.5. It is working well, no issues so far.
My sincere gratitude to you dear Bad Mister for your timely response.
Thank you so much..:D